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Home - Products - Endocrinology/Hormones - Estrogen Receptor/ERR - GDC-0927 racemate

GDC-0927 racemate

CAS No. 1443983-36-5

GDC-0927 racemate( GDC0927 racemate )

Catalog No. M11883 CAS No. 1443983-36-5

GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GDC-0927 racemate
  • Note
    Research use only, not for human use.
  • Brief Description
    GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
  • Description
    GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
  • In Vitro
    GDC-0927 Racemate (Example 1) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate reduces the viability of MCF7 cells with an IC50 of 0.21 nM.
  • In Vivo
    ——
  • Synonyms
    GDC0927 racemate
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen Receptor/ERR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1443983-36-5
  • Formula Weight
    461.533
  • Molecular Formula
    C28H28FNO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC1=CC=C2C(C(C)=C(C3=CC=CC(O)=C3)C(C4=CC=C(OCCN5CC(CF)C5)C=C4)O2)=C1
  • Chemical Name
    2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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